• Analysis of the mechanisms involved in the immunoregulatory effect of human bone marrow mesenchymal stem cells

    Financed by: COFIN/MIUR 40% (Ministero dell’Università e della Ricerca Scientifica)
    Coordinator: Responsabile nazionale: Prof. Sergio Romagnani (Università di Firenze); Responsabile per Verona: Dr. Mauro Krampera
    Project length: 2005 - 2007

  • Treatment of neurological autoimmune diseases with mesenchymal stem cells: analysis of efficacy and molecular mechanisms

    Financed by: Fondazione CARIVERONA
    Coordinator: Coordinatore: Prof. Bruno Bonetti; Responsabile di unità operativa: Dr. Mauro Krampera
    Project length: 2005 - 2007

  • Influence of stromal microenviroment derived from mesenchymal stem cells on neoplastic growth and anti-cancer innate and adaptive immunity

    Financed by: COFIN/MIUR 40% (Ministero dell’Università e della Ricerca Scientifica)
    Coordinator: Responsabile nazionale: Prof. Sergio Romagnani (Università di Firenze); Responsabile per Verona: Dr. Mauro Krampera
    Project length: 2007 - 2009

  • CASCADE (Cultivated Adult Stem Cells as Alternative for Damaged tissuE)

    CASCADE, Cultivated Adult Stem Cells as Alternative for Damaged tissuE, is a consortium granted by the 7th Framework Program of the European Commission. It has the aim to develop processes following Good Manufacturing Practice (GMP) for producing adult stem cells, more precisely for the generation of Mesenchymal Stromal/Stem Cells (MSCs).

    Financed by: 7° Programma Quadro della Ricerca e Sviluppo dell’Unione Europea
    Coordinator: Coordinatore europeo: Dr. Luc Sensebè, Tours, France; Responsabile per Verona: Dr. Mauro Krampera
    Project length: 2009 - 2012

    http://www.cascade-7fp.eu/egroupware/sitemgr/sitemgr-site/?page_name=Presentation
  • Exploitation of the regenerative and immune regulation properties of mesenchymal stem cells for the treatment of bone, neurological and cardiological diseases

    Financed by: Fondazione CARIVERONA
    Coordinator: Coordinatore: Dr. Mauro Krampera
    Project length: 2009 - 2011

  • New gene and cell therapy-based approaches to the treatment of Cystic Fibrosis

    Financed by: Ministero della Salute – Direzione Generale della Ricerca Scientifica e Tecnologica
    Coordinator: Coordinatore: D.ssa Anna Tamanini (Centro Regionale per la Fibrosi Cistica); Responsabile di unità operativa: Dr. Mauro Krampera
    Project length: 2010 - 2013

  • Assessment of the physiological role and regenerative properties of Leptomeningeal Stem Cells (LeSC) in spinal cord injury

    Financed by: GALM (Gruppo di Animazione Lesionati Midollari)
    Coordinator: Responsabile: Dr. Mauro Krampera
    Project length: 2010 - 2013

  • REBORNE (Regenerating Bone defects using New biomedical Engineering approaches)

    Aim of REBORNE European consortium is to perform clinical trials using advanced biomaterials and stem cells triggering bone healing in patients. In order to reach this goal, 5 phase I clinical studies with 20 patients are proposed in 12 clinical centres spread in 8 European countries.

    Financed by: 7° Programma Quadro della Ricerca e Sviluppo dell’Unione Europea
    Coordinator: Coordinatore europeo: Dr. Pierre Layrolle, INSERM, France; Responsabile per Verona: Dr. Mauro Krampera
    Project length: 2010 - 2015

    http://www.reborne.org
  • In vivo use of mesenchymal stem cells (MSC) for bone regeneration in maxillo-facial surgery

    Financed by: Ministero della Salute – Direzione Generale della Ricerca Scientifica e Tecnologica
    Coordinator: Coordinatore: Dr. Mauro Krampera
    Project length: 2010 - 2012

  • Comparison of the immune regulatory properties of mesenchymal stem cells of different origin and other adult stem cells

    Financed by: COFIN/MIUR 40% (Ministero dell’Università e della Ricerca Scientifica, Coordinatore scientifico: Prof. Enrico Maggi)
    Coordinator: Responsabile nazionale: Prof. Enrico Maggi; Responsabile per Verona: Dr. Mauro Krampera
    Project length: 2010 - 2012

  • Bone marrow mesenchymal stem cells (MSC) for bone and corneal regeneration and immunotherapy of graft-versus-host disease (GvHD) following allogeneic hematopoietic stem cell transplantation

    Aims of the project are: 1) phase I, perspective, uncontrolled, single arm pilot study enrolling up to 22 patients, aimed at evaluating tolerability and, secondly, safety and efficacy of the employment of human autologous mesenchymal stem cells (MSC) derived from bone marrow, associated to inorganic carrier (Orthoss) and bone morphogenetic protein-7 (BMP-7) in the repair of scaphoid bone defect (Unit 1 – Sezione di Ematologia, Università degli Studi di Verona; U.O.C. di Medicina Trasfusionale d.O. e U.O.C. di Chirurgia della Mano d.O., AOUI Verona); 2) preclinical studies to assess MSC regenerative potential in maxillo-facial bone defects to set up a phase I pilot study (Unit 1 – Sezione di Ematologia, Università degli Studi di Verona; U.O.C. di Medicina Trasfusionale d.O., AOUI Verona; Sezione di Odontoiatria e Chirurgia Maxillo-Facciale, Università degli Studi di Verona); 3) preclinical studies to assess MSC regenerative potential in severe and bilateral corneal lesions, not suitable for limbal stem cell transplantation, to set up a phase I pilot study (Unit 2 – Fondazione Banca degli Occhi del Veneto – Onlus, Venezia-Zelarino); 4) preclinical studies to assess MSC immunoregolatory properties in acute GvHD following allogeneic hematopoietic stem cell transplantation, to set up a phase I pilot study (Unit 1 – Sezione di Ematologia, Università degli Studi di Verona, e U.O.C. di Medicina Trasfusionale d.O., AOUI Verona; Unit 3 – Dipartimento di Terapie Cellulari ed Ematologia, Laboratorio di Terapie Cellulari Avanzate – USSL 6, Vicenza)

    Financed by: Fondazione Cariverona
    Coordinator: Prof. Mauro Krampera
    Project length: 2013 - 2017

  • Bone marrow mesenchymal stem cells (MSC) for bone and corneal regeneration and immunotherapy of graft-versus-host disease (GvHD) following allogeneic hematopoietic stem cell transplantation

    Financed by: Ricerca Sanitaria Finalizzata - Regione Veneto 2012
    Coordinator: Coordinatore: Prof. Mauro Krampera (Dr. Giuseppe Aprili fino al 2014)
    Project length: 2012 - 2017

Ongoing projects